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No particular dose adjustment recommended when tofacitinib coadministered with potent CYP2C19 inhibitors; lessen tofacitinib dose if coadministered with both equally reasonable CYP3A4 and strong CYP2C19 inhibitors .Inhibition of platelet aggregation by clopidogrel is solely resulting from an Energetic metabolite. Clopidogrel is metabolized to this